Phenotypic and functional characterization of Bst+/- mouse retina

Phenotypic and functional characterization of Bst+/− mouse retina

The belly spot and tail (Bst(+/-)) mouse phenotype is caused by mutations of the ribosomal protein L24 (Rpl24). Among various phenotypes in Bst(+/-) mice, the most interesting are its retinal abnormalities, consisting of delayed closure of choroid fissures, decreased ganglion cells and subretinal vascularization. We further characterized the Bst(+/-) mouse and investigated the underlying molecu...

Phenotypic and Functional Characterization

A study of cell surface phenotypes of PBL of myasthenia gravis (MG) patients showed that their T cells had a significantly higher percentage of 4B4+ T cells (the helper/inducer subset) than ageand sex-matched controls. The PBL of MG patients proliferated significantly higher than those of normal subjects (NS) in response to the purified a chain of the acetylcholine receptor (AChR). Anti-AChR an...

Functional and Phenotypic Characterization

Phenotypic and Functional Characterization

Phenotypic and Functional Characterization

Although the CD5 (T1) antigen was initially described as a pan-T cell membrane glycoprotein, we report that 14 of 40 normal individuals were found to have 5% or greater of their blood mononuclear cells characterized as CD3 (T3)+ but CDSby dual immunofluorescence flow cytometry. These cells expressed normal quantities of surface CD3 and CD2 but low levels of CD7, were CD8' and CD4-, and CD16-. I...